안녕하세요.

아래와 같이 Soft Matter 분야에서 저명하신 Prof. Ludwik Leibler를 모시고,

특별세미나를 개최하오니 관심 있는 분들의 많은 참석 부탁 드립니다.

◈ 특 별 세 미 나 ◈

제 목 : Adhesion, hemostasis and organ repair by nanoparticle solutions

연 사 : Prof. Ludwik Leibler (Matière Molle et Chimie, ESPCI ParisTech),

일 시 : 2014. 12. 5 (금) 오후 3시

장 소 : KI Building Matrix Hall

◈ 초록

Adhesives and glues are made of polymers. We introduce a novel concept of adhesion by nanoparticle solutions¹.

First we demonstrate the method by assembling hydrogels. To make a strong junction between two surfaces it suffices to spread a drop of a nanoparticle solution on one surface and press the other into a contact for few seconds. Nanoparticles act as connectors and bring strength to the junction whereas gel or tissue macromolecules adsorbed on to the nanoparticles assure fracture resistance. We showed the efficiency of the method, which we call nanobridging, for natural and synthetic hydrogels and various sorts of nanoparticles such as silica, silicates, nanocrystals of cellulose or carbon nanotubes.

As a first application, we extended the concept of nanobridging to biological tissues and demonstrated that the method can be used in vivo in animals to close wounds even for soft organs such as liver and in hemorrhagic conditions².  We also show how nanoparticles can be used for hemostasis after organ resection. The approach proved easy to apply, rapid and efficient in situations when conventional methods are traumatic or fail. Nanoparticle solutions also allow fixing medical devices to tissues and organs such as the beating heart.

Use of nanoparticles as adhesives opens many fundamental questions at frontier between chemistry, physics, biology and medicine and new avenues for applications in emerging technologies such as robotics or microfluidics and also in clinical practice and surgery.

References:

1. S. Rose et al. Nanoparticle solutions as adhesives for gels and biological tissues. Nature 505, 382–385 (2014).

2. A. Meddahi-Pellé et al. Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles. Angew. Chem. Int. Ed. 126, 6487 (2014).