- [생명과학과-지식서비스공학과] 5월 첫수융합포럼 안내 The First Wednesday Multidisciplinary Forum, May 8, 2013
- 관리자 |
- 2013-05-02 13:09:50|
- 9101
첫수 융합포럼 개최 안내 The First Wednesday Multidisciplinary Forum |
생명과학과 및 지식서비스공학과가 공동으로 주관하는 5월
첫수 융합포럼에 여러분을 초대합니다.
Department of Biological Sciences and Department of Knowledge Service Engineering would like to invite faculty members and students to "The First Wednesday Multidisciplinary Forum” on May 8(Wed), 2013.
❏ 일시 : 2013. 5. 8(수) 12:00
Date : May
8(Wed) 12:00
❏ 장소 : 창의학습관(E11) 101호
Venue : Room #101, Creative Learning Bldg. (#E11)
❏ 연사 및 발표 주제
학과명 Dept. |
연사 Speaker |
발표 주제 Topic to present |
생명과학과 Department of Biological Sciences, KAIST |
한진희 교수 Prof. Jin-Hee Han |
① Optogenetic writing
and retrieving an associative memory in mouse brain |
지식서비스공학과 Department of Knowledge Service Engineering, KAIST |
Aviv Segev 교수 Prof. Aviv Segev |
② Perspectives of Knowledge Formation
and Information Retrieval |
❏ Abstract
① The lateral amygdala (LA) has been proposed as
a critical site for fear memory storage and, long-term potentiation (LTP) at LA
synapses induced by fear conditioning has been thought to be the cellular
mechanism underlying fear memory formation. However, similar synaptic changes
are also observed in upstream areas, such as the medial geniculate nucleus
(MGN) and auditory cortex (AC), raising the critical question of where the fear
memory is actually formed and stored. Here we used optogenetic approach to determine
if direct stimulation of the presynaptic auditory projections in the LA can
serve as a conditioned stimulus (CS) that, when paired with a foot shock
unconditioned stimulus (US), can drive fear conditioning. Mice were injected
with AAV-ChR2 in the two main auditory pathways to LA, MGN and AC, sending
auditory information into the LA during auditory fear conditioning. Optical
photostimulation was used to activate ChR2-expressing presynaptic axons in the
LA as a CS for fear conditioning. 24 hours later, the same optogenetic CS
produced robust freezing responses while control mice injected with AAV-GFP did
not. In parallel, we also examined LTP induction in LA slices with ChR2
expression in MGN and AC projections to LA neurons. Whole-cell patch recording showed
that pairing photo-stimulation (3 Hz) of auditory projections in LA with
postsynaptic current injection produced strong LTP at LA synapses. Our data
provide compelling evidence that fear memory can be formed in the LA synapses
independent of the activity of upstream areas delivering auditory information
and LTP at the LA synapses may underlie fear memory formation.
② The world today is characterized by
too much knowledge. With so much knowledge readily accessible, the question is:
what can we do with it. The task at-hand therefore
is how to extract and organize the knowledge so that it can be deployed
effectively as services. Methods of large scale knowledge manipulation can be
applied in fields such as web services, multilingual patent extraction, and trend analysis
from patents and from academic publications based on social network
methods.
❏ 간단한 점심식사를 준비할 예정입니다.
Refreshments will be served for free.
❏ 관련문의 /Inquiry :
생명과학과 최은주/ Ext. 2603 echoi@kaist.ac.kr
지식서비스공학과 최진희 / Ext. 1603, choijh84@kaist.ac.kr
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