- [COVER PAGE] Illusionary polymerase activity triggered by metal ions: Use for molecular logic-gate operations
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- 2011-08-25 15:52:42|
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- 2011-08-25 15:52:42|
Ki Soo Park, Cheulhee Jung and Hyun Gyu Park
Angewandte Chemie International Edition, 49(50), 9757-9760, (2010.12.10)
Article first published online: 26 OCT 2010
DOI: 10.1002/anie.201004406
http://onlinelibrary.wiley.com/doi/10.1002/anie.201004406/abstract
Abstract
Metal ion, an astonishing illusionist: In a new concept, “illusionary” polymerase activity is intentionally triggered at T–T and C–C mismatched primers by Hg2+ and Ag+ ions, respectively. A novel strategy to construct molecular-scale logic gates utilizes the nonnatural polymerase activity induced by the metal ions by rational design of the primers and selection of the type of DNA polymerase (see picture).
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