Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology

Recent Achievements

제목

[Inside front cover]SERS‐Active‐Charged Microgels for Size‐ and Charge‐Selective Molecular Analysis of Complex Biological Samples

Title: SERSActiveCharged Microgels for Size and ChargeSelective Molecular Analysis of Complex Biological Samples

Author: Dong Jae Kim, SungGyu Park, DongHo Kim,* and ShinHyun Kim*

Journal: Small, 2018, 14, 1802520

Abstract: Surfaceenhanced Raman scattering (SERS) provides a dramatic increase of Raman intensity for molecules adsorbed on nanogaprich metal nanostructures, serving as a promising tool for molecular analysis. However, surface contamination caused by protein adsorption and low surface concentration of small target molecules reduce the sensitivity, which severely restricts the use of SERS in many applications. Here, charged microgels containing agglomerates of gold nanoparticles (Au NPs) are designed using dropletbased microfluidics to provide a reliable SERS substrate with molecular selectivity and high sensitivity. The limiting mesh size of hydrogel enables the autonomous exclusion of large proteins and the charged matrix concentrates oppositely charged small molecules through electrostatic attraction. As nanogaps among Au NPs in the agglomerates enhance Raman intensity, Raman spectrum of the adsorbed molecules is selectively measured with high sensitivity in the absence of interruption from adhesive proteins. Therefore, the SERSactivecharged microgels can be used for direct analysis of pristine biological samples without the pretreatment steps of separation and concentration, which are commonly a prerequisite for Raman analysis. For the purpose of demonstration, a direct detection of fipronil sulfone with partial negative charges, a metabolite of toxic insecticide, dissolved in eggs using the positively charged microgels without any pretreatment of the samples, is shown. 

 

 

 

0

추천하기

0

반대하기

첨부파일 다운로드

등록자관리자

등록일2018-11-08

조회수2,014

  • 페이스북 공유
  • 트위터 공유
  • Google+ 공유
  • 인쇄하기
 
스팸방지코드 :
사진제목
Title:Three-Dimensional Interlocking Interface: Mechanical Nanofastener for HighInterfacial Robustness of Polymer Electrolyte Membrane Fuel Cells Author: SeongminYuk, Min-Ju Choo, Dongyoung Lee, Hwanuk Guim, Tae-Ho Kim, Dai Gil Lee, SungyuChoi, Dong-Hyun Lee, Gisu Doo, Young Taik Hong and Hee-Tak Kim Journal:Advanced Materials, 2017, 29, 1603056 Abstract: A scalable nano-fastener fe...
Title: Metabolic Engineering of Escherichia coli for the Production of 3‑Hydroxypropionic Acid and Malonic Acid through β‑Alanine Route   Author: Chan Woo Song, Je Woong Kim, In Jin Cho, and Sang Yup Lee   Journal: ACS Syn. Biol., 5(11): 1256-1263 (2016. 11)   ABSTRACT: Escherichia coli was metabolically engineered t...
Title: A Low-Voltage Organic Complementary Inverter with High Operation Stability and Flexibility Using an Ultrathin iCVD Polymer Dielectric and a Hybrid Encapsulation LayerAuthor: Hyejeong Seong, Junhwan Choi, Byung Chul Jang, Mincheol Kim, Seunghyup Yoo, Sung-Yool Choi, and Sung Gap Im* Journal: Advanced Electronic Materials, 2016, Vol.2, p.1500385  Abstract: A low-volta...
Title: Synthesis of Ultrathin,Homogeneous Copolymer Dielectrics to Control the Threshold Voltage of OrganicThin-Film Transistors Author: Kwanyong Pak , Hyejeong Seong , Junhwan Choi , Wan Sik Hwang , and Sung Gap Im*Journal: Advanced Functional materials, 2016, Vol.26, p.6574–6582AbstractThis work demonstrates that thresholdvoltage (VT) of organicthin-fi lm transistors (OTFTs) can be contro...
Title : High molecular weight bio furan-based co-polyesters for food packaging applications: synthesis, characterization and solid-state polymerization Authors : Sungmin Hong, Kyung-Deok Min, Byeong-Uk Nam and O Ok Park* Journal : Green Chemistry, 2016, Vol.18, p.5142-5150 AbstractThe goal of this study was to develop ecofriendly bioplastics, which could be applicable in bevera...