Ki Soo Park, Cheulhee Jung and Hyun Gyu Park
Angewandte Chemie International Edition, 49(50), 9757-9760, (2010.12.10)
Article first published online: 26 OCT 2010
Metal ion, an astonishing illusionist: In a new concept, “illusionary” polymerase activity is intentionally triggered at T–T and C–C mismatched primers by Hg2+ and Ag+ ions, respectively. A novel strategy to construct molecular-scale logic gates utilizes the nonnatural polymerase activity induced by the metal ions by rational design of the primers and selection of the type of DNA polymerase (see picture).