Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology

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[COVER PAGE] Illusionary polymerase activity triggered by metal ions: Use for molecular logic-gate operations

Ki Soo Park, Cheulhee Jung and Hyun Gyu Park

Angewandte Chemie International Edition, 49(50), 9757-9760, (2010.12.10)


Article first published online: 26 OCT 2010

DOI: 10.1002/anie.201004406

http://onlinelibrary.wiley.com/doi/10.1002/anie.201004406/abstract


Abstract

Metal ion, an astonishing illusionist: In a new concept, “illusionary” polymerase activity is intentionally triggered at T–T and C–C mismatched primers by Hg2+ and Ag+ ions, respectively. A novel strategy to construct molecular-scale logic gates utilizes the nonnatural polymerase activity induced by the metal ions by rational design of the primers and selection of the type of DNA polymerase (see picture).


 

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Ki Soo Park, Cheulhee Jung and Hyun Gyu Park Angewandte Chemie International Edition, 49(50), 9757-9760, (2010.12.10) Article first published online: 26 OCT 2010 DOI: 10.1002/anie.201004406 http://onlinelibrary.wiley.com/doi/10.1002/anie.201004406/abstract Abstract Metal ion, an astonishing illusionist: In a new concept, “illusionary” polymerase activity is intentionally...