Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology

Recent Achievements


[Cover Paper]Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes



Actinomycetes contain diverse antibiotic gene clusters that have not been fully explored yet. Existing and recently developed tools now allow us to perform metabolic engineering of actinomycetes to enable the identification and enhanced production of novel antibiotic compounds. In pages 15–26 of this issue, Sang Yup Lee and colleagues discuss state-of-the art techniques, tools and strategies for the metabolic engineering of actinomycetes. Cover images from Sang Yup Lee and cover design by Ernesto Andrianantoandro.


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Title:Three-Dimensional Interlocking Interface: Mechanical Nanofastener for HighInterfacial Robustness of Polymer Electrolyte Membrane Fuel Cells Author: SeongminYuk, Min-Ju Choo, Dongyoung Lee, Hwanuk Guim, Tae-Ho Kim, Dai Gil Lee, SungyuChoi, Dong-Hyun Lee, Gisu Doo, Young Taik Hong and Hee-Tak Kim Journal:Advanced Materials, 2017, 29, 1603056 Abstract: A scalable nano-fastener fe...
Title: Metabolic Engineering of Escherichia coli for the Production of 3‑Hydroxypropionic Acid and Malonic Acid through β‑Alanine Route   Author: Chan Woo Song, Je Woong Kim, In Jin Cho, and Sang Yup Lee   Journal: ACS Syn. Biol., 5(11): 1256-1263 (2016. 11)   ABSTRACT: Escherichia coli was metabolically engineered t...
Title: A Low-Voltage Organic Complementary Inverter with High Operation Stability and Flexibility Using an Ultrathin iCVD Polymer Dielectric and a Hybrid Encapsulation LayerAuthor: Hyejeong Seong, Junhwan Choi, Byung Chul Jang, Mincheol Kim, Seunghyup Yoo, Sung-Yool Choi, and Sung Gap Im* Journal: Advanced Electronic Materials, 2016, Vol.2, p.1500385  Abstract: A low-volta...
Title: Synthesis of Ultrathin,Homogeneous Copolymer Dielectrics to Control the Threshold Voltage of OrganicThin-Film Transistors Author: Kwanyong Pak , Hyejeong Seong , Junhwan Choi , Wan Sik Hwang , and Sung Gap Im*Journal: Advanced Functional materials, 2016, Vol.26, p.6574–6582AbstractThis work demonstrates that thresholdvoltage (VT) of organicthin-fi lm transistors (OTFTs) can be contro...
Title : High molecular weight bio furan-based co-polyesters for food packaging applications: synthesis, characterization and solid-state polymerization Authors : Sungmin Hong, Kyung-Deok Min, Byeong-Uk Nam and O Ok Park* Journal : Green Chemistry, 2016, Vol.18, p.5142-5150 AbstractThe goal of this study was to develop ecofriendly bioplastics, which could be applicable in bevera...