Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology

Recent Achievements

제목

[Cover Paper]Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

 

[ABSTRACT]

Actinomycetes contain diverse antibiotic gene clusters that have not been fully explored yet. Existing and recently developed tools now allow us to perform metabolic engineering of actinomycetes to enable the identification and enhanced production of novel antibiotic compounds. In pages 15–26 of this issue, Sang Yup Lee and colleagues discuss state-of-the art techniques, tools and strategies for the metabolic engineering of actinomycetes. Cover images from Sang Yup Lee and cover design by Ernesto Andrianantoandro.

 


첨부파일 다운로드

등록자배성순

등록일2014-12-29

조회수6,465

  • 페이스북 공유
  • 트위터 공유
  • Google+ 공유
  • 인쇄하기
 
사진제목
Title: Polyketide bio-derivatization using the promiscuous acyltransferase KirCII Author: Musiol-Kroll, E.M., Zubeil, F., Schafhauser, T., Hartner, T., Kulik, A., McArthur, J., Koryakina, I., Wohlleben, W., Grond, S., Williams, G.J., Lee, S.Y., and Weber, T. Journal: ACS Synth. Biol., 2017, 6 (3), pp 421–427   Abstract: During polyketide bios...
Title: Structure and function of the N-terminal domain of Ralstonia eutropha polyhydroxyalkanoate synthase, and the proposed structure and mechanisms of the whole enzyme Author: Kim, Y-J., Choi, S.Y., Kim, J.E., Jin, K.S., Lee, S.Y., Kim, K-J. Journal: Biotechnol. J., 12(1):  1-12 (2017. 1) Abstract: Polyhydroxyalkanoates (PHAs) are natural...
Title: Crystal structure of Ralstonia eutrophapolyhydroxyalkanoate synthase C-terminal domain and reaction mechanismsAuthor: Kim, J.E., Kim, Y-J., Choi, S.Y., Lee, S.Y.,Kim, K-J.Journal: Biotechnol. J., 12(1):  1-12(2017. 1)Abstract:Polyhydroxyalkanoates(PHAs) are natural polyesters synthesized by numerous microorganisms as energyand reducing power storage materials, and h...
Title: Biosynthesis of poly(2-hydroxyisovalerate-co-lactate) by metabolically engineered Escherichia coli   Author: Yang, J.E., Kim, J.W., Oh, Y.H., Choi, S.Y., Lee, H., Park, A.-R., Shin, J., Park, S.J., and Lee, S.Y.  Journal: Biotechnol. J. , 11(12): 1572-1585 (2016. 12)  Abstract: Polyhydroxyalkanoates (PHAs) containing 2-hydroxy...
Title: Fluorescent Block Copolymer-MoS2Nanocomposites for Real-Time Photothermal Heating and Imaging Author: Chan Ho Park, Hongseok Yun, Hyunseung Yang, JunhyukLee, and Bumjoon J. Kim* Journal: Advanced Functional Materials, 2017, 27, 1604403 Abstract:Novel self-monitoring photothermal (PT) agents are developed using optothermally responsive block copolymer-MoS2 ...