Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology


Andreas Sebastian Bommarius (from GeorgiaTech)

Adjunct professor

Tel : +1-404-385-1334
E-mail :
Homepage :
Massachusetts Institute of Technology, Cambridge, MA B.S. Ch.E. Chemical Engineering 1982
Technical University of Munich, Munich/Germany Diploma Chemistry 1984
Massachusetts Institute of Technology, Cambridge, MA Ph.D. Chemical Engineering 1989
RWTH Aachen, Aachen/Germany Habilitation Technical Chemistry 2000

Employment and Professional Experience
Professor Georgia Institute of Technology, Atlanta, GA August 2000 - present
- School of Chemical & Biomolecular Engineering (since August 2000), School of Chemistry and Biochemistry
(since August 2001), Bioengineering Program (since January 2008)

Awards and Honors
Keynote speaker, Zing Conference Biocatalysis, Xcaret/Mexico, December 2012
Ollis Lecture, North Carolina State University, Raleigh, NC, August 29, 2011
Director, NSF-I/UCRC “Center for Pharmaceutical Development”, as of February 2010
Co-chair, Engineering Conference Intl., “Enzyme Engineering”, in Groningen/Netherlands; Sept. 2009
Keynote speaker, 4th Brazilian Workshop on Biocatalysis & Biotransformation, São Carlos/Brazil, 2008
Fellow, American Institute of Medical and Biological Engineering (AIMBE), February 2008
Keynote speaker, 11th Japanese Symposium on Biocatalysis, Tottori/Japan, January 2008
Keynote speaker, 6th European Conference on Protein Stabilization, Bratislava/Slovakia, Sept. 2004
Co-chair, Gordon Research Conference ‘Biocatalysis’, in Meriden/NH, July 2004
Co-chair, Engineering Foundation Conference, “Complex Fluids”, in Il Ciocco/Italy, Jan. 1998
Keynote Speaker, Biotrans 97 Conference, La Grande Motte/France, September 1997
Eli Lilly Lecturer, Indianapolis, IN, October 1995

Research interests
1. Development of Novel Biocatalysts (selected examples)
- Cellobiohydrolases
- Beta-lactam hydrolases
- Enoate reductases
- NAD(P)H oxidases
2. Investigation and Enhancement of Protein Stability
- Effects of buffer salts on protein stability
- Short-term tests of aggregation propensities of proteins
- Determination of long-term biocatalyst process stability through short-term experiments
3. Data-driven protein engineering
- Structure-guided consensus concept
- Finding relevant residues with Boolean learning/support vector machine techniques
- Improving directed evolution through pooling

Selected Publications
1. J. Rubin, L. Linden, W.M. Coco, A.S. Bommarius, S.H. Behrens, “Salt-Induced Aggregation of a
Monoclonal Human Immunoglobulin G1”, J. Pharm. Sci. 2013, 102, 377-386
2. J.K. Blum, W.D. Ricketts, and A.S. Bommarius, “Improved thermostability of amino ester hydrolase
(AEH) by combining B-FIT analysis and structure-guided consensus method”, J. Biotechnol. 2012, 160,
3. M.J. Abrahamson, E. Vazquez-Figueroa, N.B. Woodall, J.C. Moore, A.S. Bommarius, “Development of a
Novel Amine Dehydrogenase for Synthesis of Chiral Amines“, Angew. Chem. Intl. Ed. 2012, 51, 3969-
4. A.L. Deaguero, J.K. Blum, and A.S. Bommarius, “Improving the Diastereoselectivity of Penicil-lin G
Acylase for Ampicillin Synthesis from Racemic Substrates”, Prot. Eng. Des. Select. 2012, 25, 135-144
5. P. Bansal, B.J. Vowell, M. Hall, M.J. Realff, J.H. Lee, A.S. Bommarius, “Elucidation of Cellulose
Accessibility, Hydrolysability and Reactivity as the Major Limitations in the Enzymatic Hydrolysis of
Cellulose”, Biores. Technol. 2012, 107, 243-250
6. H.S. Castillo, A.M. Ousley, A. Duraj-Thatte, K.N. Lindstrom, D.D. Patel, A.S. Bommarius, B. Azizi,
“The Role of Residue C410 on Activation of the Human Vitamin D Receptor by Various Ligands”, J.
Steroid Biochem. Mol. Biol. 2012, 128, 76-86
7. M. Hall, J. Rubin, S.H. Behrens, and A.S. Bommarius, “The Cellulose-Binding Domain of Cellobiohydrolase
Cel7A from Trichoderma reesei Is Also a Thermostabilizing Domain”, J. Biotechnol. 2011,
155, 370-376
8.Mélanie Hall and Andreas S. Bommarius, "Enantioenriched compounds via enzyme-catalyzed redox
reactions”, Chem. Rev. 2011, 111, 4088-4110
9. J.T. Park, J.I. Hirano, V. Thangavel, B.R. Riebel, A.S. Bommarius, “NAD(P)H oxidase V from
Lactobacillus plantarum V (NoxV) displays enhanced operational stability even in absence of reducing
agents”, J. Mol. Catal. B Enz. 2011, 71, 159-165
10. Y. Yanto, C. K. Winkler, S.J. Lohr, M. Hall, K. Faber, and A.S. Bommarius, “Asymmetric Bioreduction
of Alkenes Using Ene Reductases YersER and KYE1, and Effects of Organic Solvents”, Org. Lett., 2011,
13, 2540-43

Bommarius Research Group
Biocatalysis, Bioprocessing, Protein Stability, Synthetic Biology, Green Chemistry