Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology

Faculty

George Georgiou (from UT Austin)

Adjunct Professor

Tel : +1-512-471-6975
E-mail : gg@che.utexas.edu
Homepage : http://www.che.utexas.edu/georgiou
Education
Ph.D., Chemical Engineering, Cornell University (1987)
M.S., Chemical Engineering, Cornell University (1983)
B.Sc., Chemical Engineering, University of Manchester Institute of Science and Technology (UMIST), England (1981)

Employment and Professional Experience
Cockrell Family Regents Chair in Engineering #9, U. Texas, Austin: 2005-Present
Professor, Section of Molecular Genetics and Microbiology, U. Texas, Austin: 2005-Present
Joe C. Walter, Jr. Endowed Chair, U. Texas, Austin: 2004-2005
Joan and Keys Curry/Cullen Trust Endowed Chair, U. Texas, Austin: 1998-2004
Professor, Dept. of Chemical Engineering, U. Texas, Austin: 1995-Present
Professor, Dept of Biomedical Engineering, U. Texas, Austin: 2001-Present
Member, Institute for Molecular and Cellular Biology, U. Texas, Austin: 1994-Present
Associate Professor, Dept. of Chemical Engineering, U. Texas, Austin: 1991-1994
Assistant Professor, Dept. of Chemical Engineering, U. Texas, Austin: 1986-1991

Awards and Honors
- Named as one of “100 Eminent Chemical Engineers of the Modern Era,” American Institute of Chemical Engineering (AIChE 2008)
- Jay Bailey Award, Society of Biological Engineers (2007)
- AMGEN Award in Biochemical Engineering (2007)
- Food, Pharmaceutical and Bioengineering Award, American Institute of Chemical Engineering (AIChE 2005)
- National Academy of Engineering (NAE 2005)
- Fellow, American Academy of Microbiology (2004)
- Fellow, American Association for the Advancement of Science (2004)
- Professional Progress Award for Outstanding Progress in Chemical Engineering, American Institute of Chemical Engineering (AIChE 2003)
- Marvin J. Johnson Award in Microbial and Biochemical Technology, American Chemical Society (ACS 2003)
- Fellow, American Institute for Medical and Biological Engineering (AIMBE 1996)
- E. Bergman Award, US-Israel Science Foundation (1995)
- Presidential Young Investigator Award, National Science Foundation (1987)

Research interests
1. Development of new technologies to aid protein engineering and drug discovery
2. Engineering of therapeutic and diagnostic antibodies
3. Engineering of novel enzymes
4. The mechanism of oxidative protein folding in bacteria
5. Protein secretion pathways in bacteria
6. Regulation of RNA turnover
7. Biologically templated nanomaterials

Selected Publications
- Feeney, M.A., Veeravalli, K., Boyd, D., Gon, S., Faulkner, M.J., Georgiou, G. & Beckwith. J., “Rewiring Major Electron Flow Pathways in E.coli by a Single Amino Acid Change in Lipoamide Dehydrogenase” Proc. Natl. Acad. Sci. USA (accepted).
- Cantor J. R., Yoo, T.-H., Dixit, A., Iverson, B.L., Forsthuber, T.G. & G. Georgiou, “Therapeutic Enzyme De-immunization by Combinatorial T-Cell Epitope Removal using Neutral Drift, Proc. Natl. Acad. Sci. USA”108:1272-77 (2011).
- Veeravalli, K., Boyd, D., Iverson, B.L., Beckwith, J. & G. Georgiou, “Laboratory Evolution of Glutathione Biosynthesis Reveals Natural Compensatory Pathways,” Nature Chem. Biol. 7:101-105 (2011).
- Stone, E.M., Chantranupong, L., & G. Georgiou, “The Second Shell Metal Ligands of Human Arginase Affect Coordination of Nucleophile and Substrate” Biochemistry 49:10582-8 (2010) PMID: 21053939
- Reddy, R.T., Ge, X., et al. & G. Georgiou, “ Isolation of Monoclonal Antibodies Without Screening by Mining the Variable Gene Repertoire of Plasma Cells,” Nature Biotechnol. 28:965-9 (2010).
- Stone, M.S, Chantranupong, L, Glazer S.E, Cherukuri, P., Breece, R.M., Tierney D.L., Curley S.A. and G. Georgiou, “Replacing Mn+2 with Co+2 in Human Arginase I Enhances Cytotoxicity Towards L-Arginine Auxotrophic Cancer Cell Lines” ACS Chemical Biology 5:333-42 (2010) PMID: 20050660
- Jung, S.T., Reddy, S., Kang, T.H, Borrok, J.M., Sandlie, I., Tucker, P.W. and G. Georgiou, “Aglycosylated IgG Variants Expressed in E. coli that Selectively Bind FcgRI Potentiate Tumor Cell Killing by Monocyte-Derived Dendritic Cells,” Proc Natl Acad Sci USA 107:604-9 (2010) PMID: 20080725

George Georgiou Research Group
Biotechnology