Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology


Mathematical Physiology의 저자 James Keener 교수 강연 세미나

유타 대학 석좌 교수님이시고 수리 생물학 바이블인 Mathematical Physiology의 저자이신 James Keener 교수님께서 수학이 어떻게 다양한 생물학 퍼즐들을 해결 할 수 있는지에 관해서 11.6 (금) 부터 11.10 (화)까지 3회의 강연을 아래와 같이 안내하여 드립니다.  

11. 6 () 16:00-17:00 자연과학동 (E6) 1501 Host: 김재경 (수리과학과)

The Mathematics of Life: Signals, Shapes and Measurements   


Abstract:  Although biological processes are undeniably complex, there are underlying mathematical principles that govern the operation of many of these.  In this talk, I will show how the combination of chemical reactions with positive feedback coupled with diffusion underlies that operation of many systems, including signaling networks, pattern forming developmental processes, and measurement-based decisions.  I will also show how mathematical modeling and analysis leads to an improved understanding of emergent and collective behaviors in cell biology.    


11. 9 () 16:00-17:00 산업경영학동 (E2) 3221 Host: 김재경 (수리과학과)

Heart Attacks can give you Mathematics:  An introduction to Cardiac Electrophysiology


Each year in  the United States, approximately a quarter of a million people die as the result of a heart attack. In most of these cases, a coronary occlusion led to the sudden onset of fibrillation, a condition, which if not arrested, is fatal. In this talk, I will give an introduction to the mathematical modelling of cardiac electrical activity and use these models to give a understanding of fatal cardiac arrhythmias and how they may be initiated.


11. 10 ()11:00-12:00 정문술빌딩(E16) 220 Host: 조광현 (바이오및뇌공학과)


The Mechanism of hook length regulation in Salmonella


The construction of flagellar motors in motile bacteria such as Salmonella is a carefully regulated genetic process.  Among the structures that are built are the basal body, the hook and the filament.  Each of these is made only after the previous one has been completed.  Furthermore the length of the hook is tightly regulated. The question that will be addressed in this talk is how Salmonella detects and regulates the length of its hooks.  The model for hook length regulation is based on the hypothesis that the hook length is determined by the rate of secretion of the length regulatory molecule FliK and a cleavage reaction with the gatekeeper molecule FlhB.  A stochastic model for this interaction is built and analyzed, showing excellent agreement with hook length data.  We will also describe how mathematical modeling led to predictions that were subsequently tested experimentally, an example of a Math Biology success story.





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