KAIST opened two cross-generation collaborative labs (CGCLs) at its main campus in April 26, 2018. KAIST initiated a program called CGCLs for the first time in order to maintain and further develop a senior professor’s academic achievements and legacy (which usually disappear upon the senior professor’s retirement) by inheriting them to a junior professor. A CGCL project is comprised of one senior professor and one to three junior professors. In this newly launched program, Systems Metabolic Engineering and Systems Healthcare (SMESH) Laboratory of Distinguished Professor Sang Yup Lee and Assistant Professor Hyun Uk Kim (both from our CBE department) was selected as one of the first CGCLs along with Acousto-Microfluidics Research Center for Next-Generation Healthcare led by Chair Professor Hyung Jin Sung in the Department of Mechanical Engineering. The SMESH laboratory will attempt to address problems of climate changes and healthcare by developing platform technologies that involve metabolic engineering, in silico cells, big data and/or machine learning.