Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology

Recent Achievements

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[Front cover picture] Cancer Treatment: Enhanced Photodynamic Cancer Treatment by Mitochondria‐Targeting and Brominated Near‐Infrared Fluorophores

Title: Cancer Treatment: Enhanced Photodynamic Cancer Treatment by MitochondriaTargeting and Brominated NearInfrared Fluorophores

Author: Ilkoo Noh, DaeYong Lee, Heegon Kim, Chan-Uk Jeong, Yunsoo Lee, Jung-Oh Ahn, Hoon Hyun, Ji-Ho Park, and Yeu-Chun Kim

Journal: Advanced science (IF:9.034)

 

Abstract: A noninvasive and selective therapy, photodynamic therapy (PDT) is widely researched in clinical fields; however, the lower efficiency of PDT can induce unexpected side effects. Mitochondria are extensively researched as target sites to maximize PDT effects because they play crucial roles in metabolismand can be used as cancer markers due to their high transmembrane potential. Here, a mitochondria targeting photodynamic therapeutic agent (MitDt) is developed. This photosensitizer is synthesized from heptamethine cyanine dyes, which are conjugated or modified as follows. The heptamethine mesoposition is conjugated with a triphenylphosphonium derivative for mitochondrial targeting, the N-alkyl side chain is modified for regulation of charge balance and solubility, and the indolenine groups are brominated to enhance reactive oxygen species generation (ROS) after laser irradiation. The synthesized MitDt increases the cancer uptake efficiency due to the lipo-cationic properties of the triphenylphosphonium, and the PDT effects of MitDt are amplified after laser irradiation because mitochondria are susceptible to ROS, the response to which triggers an apoptotic anticancer effect. Consequently, these hypotheses are demonstrated by in vitro and in vivo studies, and the results indicate strong potential for use of MitDts as efficient single-moleculebased PDT agents for cancer treatment.

 


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등록일2018-03-29

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Liquid-Impermeable Inverse Opals with Invariant Photonic Bandgap (pages 1282–1287) Hyelim Kang, Joon-Seok Lee, Won Seok Chang and Shin-Hyun Kim Article first published online: 10 DEC 2014 | DOI: 10.1002/adma.201404706 [ABSTRACT] Omniphobic inverse opals are created by structurally and chemically modifying the surface of inverse opals through reactive ion etching. During the etching, ...
Robust Microfluidic Encapsulation of Cholesteric Liquid Crystals toward Photonic Ink Capsules,` Advanced Materials, 27, 627−633 (2015) Sang Seok Lee, Bomi Kim, Su Kyung Kim, Jong Chan Won, Yun Ho Kim, and Shin-Hyun Kim 관련기사:  http://www.hellodd.com/news/article.html?no=51837  [ABSTACT] Robust photonic microcapsules are created by microfluidic encapsulation of chol...
Cofactor-Free Light-Driven Whole-Cell Cytochrome P450 Catalysis Angew. Chem. Int. Ed. 54(3):969-973 (Jan. 12 2015)   Park JH, Lee SH, Cha GS, Choi DS, Nam DH, Lee JH, Lee JK, Yun CH, Jeong KJ*, Park, CB*  [ABSTRACT] Cytochromes P450 can catalyze various regioselective and stereospecific oxidation reactions of non-functionalized hydrocarbons. Here, we have designed a novel ...
Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes Tilmann Weber, Pep Charusanti, Ewa Maria Musiol-Kroll, Xinglin Jiang, Yaojun Tong, Hyun Uk Kim, Sang Yup Lee  [ABSTRACT] Actinomycetes contain diverse antibiotic gene clusters that have not been fully explored yet. Existing and recently developed tools now allow us to perform metabolic ...
New Platform for cytochrome P450 reaction combining in situ immobilization on biopolymer.   Lee JH, Nam DH, Lee SH, Park JH, Park SJ, Lee SH, Park CB, Jeong KJ   Bioconjugate Chemistry (2014) 25(12):2101-2104.   [ABSTRACT]We describe an efficienct chemical conversion platform with in situ immobilization of P450-BM3 on poly(3-hydroxybutyrate) granules. Through fusion ...