Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology

Recent Achievements

제목

[Front cover picture] Cancer Treatment: Enhanced Photodynamic Cancer Treatment by Mitochondria‐Targeting and Brominated Near‐Infrared Fluorophores

Title: Cancer Treatment: Enhanced Photodynamic Cancer Treatment by MitochondriaTargeting and Brominated NearInfrared Fluorophores

Author: Ilkoo Noh, DaeYong Lee, Heegon Kim, Chan-Uk Jeong, Yunsoo Lee, Jung-Oh Ahn, Hoon Hyun, Ji-Ho Park, and Yeu-Chun Kim

Journal: Advanced science (IF:9.034)

 

Abstract: A noninvasive and selective therapy, photodynamic therapy (PDT) is widely researched in clinical fields; however, the lower efficiency of PDT can induce unexpected side effects. Mitochondria are extensively researched as target sites to maximize PDT effects because they play crucial roles in metabolismand can be used as cancer markers due to their high transmembrane potential. Here, a mitochondria targeting photodynamic therapeutic agent (MitDt) is developed. This photosensitizer is synthesized from heptamethine cyanine dyes, which are conjugated or modified as follows. The heptamethine mesoposition is conjugated with a triphenylphosphonium derivative for mitochondrial targeting, the N-alkyl side chain is modified for regulation of charge balance and solubility, and the indolenine groups are brominated to enhance reactive oxygen species generation (ROS) after laser irradiation. The synthesized MitDt increases the cancer uptake efficiency due to the lipo-cationic properties of the triphenylphosphonium, and the PDT effects of MitDt are amplified after laser irradiation because mitochondria are susceptible to ROS, the response to which triggers an apoptotic anticancer effect. Consequently, these hypotheses are demonstrated by in vitro and in vivo studies, and the results indicate strong potential for use of MitDts as efficient single-moleculebased PDT agents for cancer treatment.

 


1

추천하기

0

반대하기

첨부파일 다운로드

등록자관리자

등록일2018-03-29

조회수3,086

  • 페이스북 공유
  • 트위터 공유
  • Google+ 공유
  • 인쇄하기
 
스팸방지코드 :
사진제목
Title: SERS‐Active‐Charged Microgels for Size‐ and Charge‐Selective Molecular Analysis of Complex Biological Samples Author: Dong Jae Kim, Sung‐Gyu Park, Dong‐Ho Kim,* and Shin‐Hyun Kim* Journal: Small, 2018, 14, 1802520 Abstract: Surface‐enhanced Raman scattering (SERS) provides a dramatic increase of Raman intensity for molecules adsorbed on nanogap‐rich meta...
Title: Aspect Ratio-ControlledSynthesis of Uniform Colloidal Block Copolymer Ellipsoids from Evaporative Emulsions Author: Jae Man Shin, YongJoo Kim, KangHee Ku, Young Jun Lee, Eun Ji Kim, Gi-Ra Yi*, and Bumjoon J. Kim* Journal: Chemistry of Materials, 30, 18, 6277-6288, Inside front cover Abstract: Block copolymers (BCPs)confined in evaporative emulsions can ass...
Title: Fully Dispersed Rh Ensemble Catalyst To Enhance Low-Temperature Activity   Author: Hojin Jeong, Geonhee Lee, Beom-Sik Kim, Junemin Bae, Jeong Woo Han, and Hyunjoo Lee*   Journal: Journal of American Chemical Society, 2018, 140, 9558-9565   Abstract: Minimizing the use of precious metal catalysts is important in many applicati...
Title: Domain Structures of Poly(3-dodecylthiophene)-Based Block Copolymers Depend onRegioregularity Author: Jin-Seong Kim, Junghun Han, Youngkwon Kim, Hyeonjung Park,Jonathan P. Coote Gila E Stein*, and Bumjoon J. Kim* Journal: Macromolecules 51, 11, 4077-4084, Outside frontcover Abstract: Microphase-separation behavior of conjugated–amorphous block copol...
Title: An Ultrastable Ionic Chemiresistor Skin with an Intrinsically Stretchable Polymer ElectrolyteAuthor: Ming Liang Jin, Sangsik Park, Jong-Seon Kim, Sung Hyun Kwon, Shuye Zhang, Min Seok Yoo, Sungwoo Jang, Hyeong-Jun Koh, Soo-Yeon Cho, So Young Kim, Chi Won Ahn, Kilwon Cho, Seung Geol Lee, Do Hwan Kim,* and Hee-Tae Jung*Journal: Advanced Materials, 2018, Vol.30, 1706851Abstract: Ultrastable se...