Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology

Faculty

Yoosik Kim (김유식)

Assistant Professor

Tel : +82-42-350-7312
Fax : +82-42-350-3910
E-mail : ysyoosik@kaist.ac.kr
Homepage : https://qcbio.wordpress.com/home

Education

- Ph.D. in Chemical and BiologicalEngineering, Princeton University, 2011

- M.A. in Chemical and BiologicalEngineering, Princeton University, 2008

- B.E. in Chemical Engineering, DartmouthCollege, 2006

- A.B. in Engineering Sciences modified withChemistry, Dartmouth College, 2006

 

Employmentand Professional Experience

- 2016-present: Assistant Professor in Dept.Chemical and Biomolecular Engineering, KAIST

- 2011-2015: Postdoctoral Researcher: Schoolof Biological Sciences, Seoul National University

 

Awardsand Honors

- TJ Park Postdoctoral Fellowship, TJ ParkFoundation, POSCO (2012)

- Wallace Memorial Honorific Fellowship,Princeton University (2010)

- Wu Prize for Excellence, PrincetonUniversity (2010)

- Donald W. Collier '44 Fellowship,Princeton University (2006)

- The Thayer School Faculty Award forAcademic Excellence, Dartmouth College (2006)

- Summa Cum Laude, Dartmouth College (2006)

- The Leon Burr Richardson Chemistry Prize(2003)

 

ResearchInterests

- Systems Biology

- Quantitative Imaging

- Bioinformatics

- RNA Biology

- Signal Transduction

 

SelectedPublication

1. Kim Y*,Yeo J*, Lee JH*, Cho J, Suh D, Kim J, and Kim VN. (2014). Deletion of human tarbp2 reveals cellular microRNA targetsand cell cycle function of TRBP. CellRep. 9, 1061-1074.

 

2. Kim Y, LeeJH, Park JE, Cho J, Yi H, and Kim VN. (2014). PKR is activated by cellulardsRNAs during mitosis and acts as a mitotic regulator. Genes Dev. 28,1310-1322.

 

3. Kim Y,Iagovitina A, Ishihara K, Fitzgerald KM, Deplancke B, Papatsenko D, andShvartsman SY. (2013). Context-dependent transcriptional interpretation ofmitogen activated protein kinase signaling in the Drosophila embryo. Chaos. 23,025105.

 

4. Kim Y, Andreu MJ,Lim B, Chung K, Terayama M, Jiménez G, Berg CA, Lu H, and Shvartsman SY. (2011). Gene Regulation byMAPK Substrate Competition. Dev Cell. 20, 880-887.

 

5. Kim Y, Paroush Z, Nairz K, Hafen E,Jiménez G, and Shvartsman SY. (2011). Substrate-dependentcontrol of MAPK phosphorylation in vivo.Mol Syst Biol. 7, 467.

 

6. Chung K*, Kim Y*, Kanodia JS, Gong E,Shvartsman SY, and Lu H. (2011). Amicrofluidic array for large-scale ordering and orientation of embryos. Nat Methods. 8, 171-176.

 

7. Kim Y, Coppey M, Grossman R, Ajuria L,Jiménez G, Paroush Z, and Shvartsman SY. (2010). MAPK Substrate Competition Integrates PatterningSignals in the Drosophila Embryo. Curr Biol. 20, 446-451.

  • Physiological function of double-stranded RNAs and innate immune response proteins

Cellular dsRNAs are emerging as a new class of signaling molecules that regulate multiple signaling pathways. dsRNAs were originally considered as signature of viral RNAs and hence, the amount and type of cellular dsRNAs were believed to be highly limited. However, single-stranded RNAs can locally adapt secondary structure and can form intramolecular dsRNAs. Studies on cellular dsRNAs are necessary to understand and unravel the extent to which this new class of biomolecules plays a role in cell fate determination. As dsRNAs are often recognized by immune response proteins, investigating regulation of these RNAs in cells will also provide an important step toward better understanding of host immune response during infection or autoimmune disease.

PKR regulations