Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology

Faculty

Sang Yup Lee (이상엽)

Distinguished Professor

Tel : +82-42-350-3930
Fax : +82-42-350-3910
E-mail : leesy@kaist.ac.kr
Homepage : http://mbel.kaist.ac.kr

 

Office Address:

Department of Chemical & Biomolecular Engineering

Korea Advanced Institute of Science and Technology (KAIST)

291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of KOREA

(Tel: 042-350-3930, Fax: 042-350-3910, e-mail: leesy@ kaist.ac.kr, http://mbel.kaist.ac.kr)

 

Current Position (Major ones)

Distinguished Professor, Department of Chemical & Biomolecular Engineering, KAIST

Dean, KAIST Institutes

Professor, Moon Soul Graduate School of Future Strategy, KAIST

Director, BioProcess Engineering Research Center, KAIST

Director, Bioinformatics Research Center, KAIST

Head, Metabolic Engineering National Research Laboratory, KAIST

Director, Fourth Industrial Revolution Intelligence Center, KAIST

Scientific Director, New Bioactive Compounds Section, Novo Nordisk Center for Biosustainability, Technical University of Denmark

Chair, World Economic Forum’s Global Future Council on Biotechnology

Member, World Economic Forum’s Global Future Council on the Fourth Industrial Revolution

 

Education:

B.S., Dept. Chemical Engineering, Seoul National Univ., Seoul, Korea (1982. 3. 1.-1986. 2.26.)

M.S., Dept. Chemical Engineering, Northwestern Univ., Evanston, IL, USA (1986. 9.1.-1987. 6.30.)

Ph.D., Dept. Chemical Engineering, Northwestern Univ., Evanston, IL, USA (1987.7.1.-1991.12.30.)

 

Academic Position:

1994-1996, Assistant Professor/ 1997-2002, Associate Professor/ 2002-2006, Professor/ 2007-present, Distinguished Professor, Dept. Chemical Engineering, KAIST

2000-present, Director, BioProcess Engineering Research Center, KAIST

2001-present, Director, BioInformatics Research Center, KAIST

2004-2010, LG Chem Chair Professor

2004-present, Honorary Professor of University of Queensland

2007-present, Director, Center for Systems and Synthetic Biotechnology, KAIST

2008-2013, Dean (Founding Dean), College of Life Science and Bioengineering, KAIST

2012-present, Honorary Professor, Institute of Microbiology, Chinese Academy of Sciences, China

2013-2015, Dean, KAIST Institutes, KAIST

2013-present, Adjunct Professor, Technical University of Denmark

2013-present, Scientific Director, New Bioactive Compounds Section, Novo Nordisk Center for Biosustainability, Technical University of Denmark

2013-present, Advisory Professor, Shanghai Jiao Tong University (SJTU), China

2014.9-present, Honorary Professor, Wuhan University, Wuhan, China

2014.9-present, Honorary Professor, Hubei University of Technology, Wuhan, China

2014.10-present, Honorary Professor, Beijing University of Chemical Technology, Beijing, China

2017.3-present, Dean, KAIST Institutes, KAIST

2017.7-present, Director, the Fourth Industrial Revolution Intelligence Center, KAIST

2017.10-present, Honorary Professor, Jiangnan University, China

2017.10-present, Honorary Professor, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, China

 

Academy Fellow/Member:

Fellow, American Academy of Microbiology, USA (2005-present)

Fellow, American Association for the Advancement of Science, USA (2007-present)

Fellow, Korean Academy of Science and Technology, Korea (2007-present)

Fellow, Society for Industrial Microbiology and Biotechnology, USA (2010-present)

Foreign Member, National Academy of Engineering, USA (2010-present)

Fellow, National Academy of Engineering of Korea, Korea (2011-present)

Fellow, American Institute of Chemical Engineers, USA (2012-present)

Fellow, American Institute of Medical and Biological Engineering, USA (2013-present)

Fellow, The World Academy of Sciences, Italy (2013-present)

Foreign Associate, National Academy of Sciences, USA (2017-present)

Fellow, National Academy of Inventors, USA (2017-present)

***As of February 2018, he is one of only 13 people in the world who are foreign member of both National Academy of Sciences USA and National Academy of Engineering USA.

 

Major Government/Public Committee Service: ~ more than 100 committees

Member, Preparation Committee for APEC Summit (2004)

Member, Presidential Advisory Council on Green Growth (2010-2011)

Founding Member, Board of Trustees, Samsung Science and Technology Foundation (2013-present)

Member, Presidential Advisory Council on Science and Technology (term 12, 13, 14, 15; 2014-2017)

Member, New Industry Private-Government Committee, Ministry of Trade, Industry and Energy (2016-present)

Member, Government Performance Evaluation Committee, Prime Minister’s Office (2016-2018)

Member, Central Environmental Policy Committee, Ministry of Environment (2018-present)

Member, National Central Strategy Committee, Government of Korea (2018-present)

 

Selected Honors/Awards:

1. The First Young Scientist's Award, The President of the Republic of Korea, Korea (1998. 2. 12.)

2. The First Elmer-Gaden Award, Biotechnology and Bioengineering, American

    Chemical Society, USA (2000. 3. 27.)

3. Citation Classic Award, ISI, USA (2000. 11. 2.)

4. The Scientist of the Month Award, Ministry of Science and Technology, Korea

    (2001. 3. 12.)

5. SeJongDaeWang Award, Korean Intellectual Property office, Korea (2001. 4. 6.)

6. National Science and Technology Medal, President of Korea, Korea (2001. 4. 21.)

7. British Chevening Scholarship Award, British Government (2001. 6.)

8. Asian Young Leader/Asian Technology Pioneer, World Economic Forum,

    Switzerland (2002. 8. 23.)

9. Professor of the Year Award, KAIST, Korea (2003. 1. 2.)

10. "Scientist to Become" Award, Ministry of Science & Technology, Korea (2003. 7.

     29.)

11. The Best Research Award, KAIST, Korea (2004. 2. 16.)

12. The 9th Young Engineer Award, National Academy of Engineering Korea, Korea   

     (2005. 3. 10.)

13. Scientist of the Year Award, Korean Science Reporters Association (KOSRA) ,

     Korea (2006. 11. 30)

14. Selected as 100 Excellent National R&D Results (2003-2005), Ministry of Science

     and Technology, Korea (2006)

15. Merck Award for Metabolic Engineering, Metabolic Engineering VII, Puerto

     Vallata, Mexico, by Merck, USA (2008.09.16)

16. 2010 Fellow Award, Society for Industrial Microbiology, San Francisco, USA

     (2010.8.)

17. The Best Research Award, KAIST, Korea (2011.2.16)

18. POSCO TJ Park Science Prize, POSCO TJ Park Foundation, Korea (2011.03.22)

19. 2011 Presidential Green Chemistry Challenge Award, United States

     Environmental Protection Agency, USA (2011.6.20)

20. Amgen Keynote Lectureship Award, Annual Meeting of the Society for Industrial

     Microbiology, New Orleans, USA (2011.7.24)

21. 2012 KAIST Top 10 R&D Achievements, KAIST, Korea (2012.2.16)

22. Marvin J. Johnson Award, American Chemical Society, USA (2012. 3. 27)

23. Charles Thom Award, Society for Industrial Microbiology and Biotechnology,

     USA (2012.8.16)

24. Fellow, American Institute of Chemical Engineers, USA (2012-present)

25. Outstanding Contribution Award (on biotechnology), Minister for Food,

     Agriculture, Forestry and Fisheries (at the International Biotechnology

    Symposium, Daegu), Korea (2012.9.21)

26. The Fifth Environmental Microbiology Lectureship Award, Society for Applied

     Microbiology-Wiley, Royal Society of Medicine, London, UK (2012.10.8)

27. Orsted Lectureship, Technical University of Denmark, Lyngby, Denmark

     (2012.10.12)

28. Amgen Biochemical Engineering Award, Beijing, China (2013.6.19)

29. The 1st Jacobus van’t Hoff Lectureship Award, Technical University of Delft,

     Delft, Netherlands (2013.11.13)

30. The Best Scientist Award of the Year, Korea Science Journalist Association,

     Korea (2013.11.29)

31. Grand Prize for Academic Excellence, KAIST, Korea (2014.02.14)

32. 2013 KAIST Top 10 R&D Achievements, KAIST, Korea (2014.02.14)

33. The Ho-Am Prize in Engineering, Ho-Am Foundation, Korea (2014.05.30)

34. The Best National R&D Achievement, Ministry of Science, ICT and Future

     Planning (2014.7.24)

35. National Order of Merit- Red Stripes from President of Korea, The 50th

     Invention Day Ceremony, Korea (2015.5.19)

36. Nature Biotechnology's Top 20 Translational Researchers of 2014 (2015.8.27)

37. Novo Nordisk Foundation Center for Biosustainability Best Innovation Award

     2015, Denmark (2015.8.31)

38. 2016 James E. Bailey Award, Hilton Hotel Union Square, San Francisco, USA

     (2016.11.15)

39. Grand Prize in Overall Accomplishments, Commemoration of the 46th

     Anniversary of Founding of KAIST, Korea (2017.02.16)

40. 2017 Korea Best Scientist and Technologist Award, President of Korea

     (2017.07.07)

41. 2017 Highly Cited Researcher, Clarivate (previously Thomson-Reuters ISI),USA

     (2017)

42. S-Oil, Grand Prize Advisor Award, S-Oil Excellent PhD Competition, Korea

     (2018.2.6)

43. George Washington Carver Award, Biotechnology Innovation Organization (BIO),

     USA (2018.7.18) 

 

Journal Editor and board member: More than 35 journals including 

1. Associate Editor, Bioprocess and Biosystems Engineering, Springer, Germany

    (2004-present)

2. Associate Editor, Biotechnology and Bioengineering, Wiley, USA (2005-present)

3. Editor-in-Chief, Biotechnology Journal, Wiley-VCH, Germany (2008-present)

4. Editor, mBio, American Academy of Microbiology, USA (2010-present)

5. Section Editor, BMC Systems Biology, BioMedCentral, UK (2010-present)

6. Associate Editor, Microbial Cell Factories, BioMedCentral, UK (2010-present)

7. Series Editor, Advanced Biotechnology Book Series, Wiley-VCH, Germany

    (2012-present)

8. Regional Editor, Journal of Biological Engineering, BioMedCentral, UK

    (2016-present)

9. Guest Editor, PNAS, National Academy of Sciences, USA (2017-present)

10. Editor-in-Chief, Metabolic Engineering, Elsevier (2018-present)

11. Founding Chair of the Editorial Board, BMC Biomedical Engineering

    (2018-present)

12. Founding Chair of the Advisory Board, BMC Chemical Engineering

    (2018-present)

Research Interests:

Metabolic engineering, Systems metabolic engineering, Systems biology/biotechnology, Synthetic biology, Systems medicine and healthcare, Biochemical engineering, Nanobiotechnology, Industrial biotechnology

 

List of 10 recent selected publications:

1. Lee, J.W., Na, D., Park, J.M., Lee, J., Choi, S., and Lee, S.Y., "Systems metabolic

    engineering of microorganisms for natural and non-natural chemicals", Nature

    Chemical Biology, 8: 536-546 (2012)

2. Na, D., Yoo, S.M., Chung, H., Park, H., Park, J.H., and Lee, S.Y., "Metabolic

    engineering of Escherichia coli using synthetic small regulatory RNAs", Nature

    Biotechnology, 31: 170-174 (2013)

3. Choi, Y.J., Lee, S.Y., "Microbial production of short-chain alkanes", Nature, 502:

    571-574 (2013)-journal cover paper

4. Park, S.H., Kim, H.U., Kim, T.Y., Park, J.S., Kim, S.-S. and Lee, S.Y., "Metabolic

    engineering of Corynebacterium glutamicum for L-arginine production", Nature

    Communications, 5: 1-9 (2014)

5. Lee, S.Y., Kim, H.U., "Systems strategies for developing industrial microbial

    strains", Nature Biotechnology, 33(10): 10611072 (2015)

6. Kim, H.U., Ryu, J.Y., Lee, J.O. and Lee, S.Y., "A systems approach to traditional

    oriental medicine", Nature Biotechnology, 33:264-268 (2015)

7. Choi, S.Y., Park, S.J., Kim, W.J., Yang, J.E., Lee, H., Shin, J., and Lee, S.Y.

    "One-step fermentative production of poly(lactate-co-glycolate) from

    carbohydrates in Escherichia coli", Nature Biotechnology, 34(4): 435-440 (2016)

8. Luo, Z.W. and Lee, S.Y. "Biotransformation of p-xylene into terephthalic acid by

    engineered Escherichia coli", Nature Communications, 8:15689, DOI:10.1038/nco 

    mms15689 (2017) 

9. Ryu, J.Y., Kim, H.U., and Lee, S.Y. "Deep learning improves prediction of drug

    drug and drugfood interactions", Proc. Nat. Acad. Sci., 201803294: 1-8 (2018)

10. Choi, Y., Park, T.J., Lee, D.C., and Lee, S.Y. "Recombinant Escherichia coli as

    a biofactory for various single- and multi-element nanomaterials", Proc. Nat.

    Acad. Sci., 115(23): 5944-5949 (2018)