The research in our group is based on the application of modeling and numerical simulation combined with experimental method to the development of microprocesses in the chemical/biological applications and understanding of chemical/biological phenomena in chemical and biological processes.
Scope of Research
■ Separation processes in a microfluidic system
Microfluidic system has several advantages in small scale chemical and biological processes. Several separation processes on microfluidic systems are under development including isoelectric focusing, extraction and simple distillation processes. Also, we are working on developing novel fluid handling methods including electrowetting and electrokinetic control of drops.
Fig.1. (a) Layout for dynamic concentration of proteins, (b) Electrokinetic generation of a single drop,
(c) Drop movement on the array of electrowetting electrodes.
■ Chemical and biological detection
The detection of specific biological molecules becomes more and more important with the development of biology into molecular regime dealing with a single cell rather than population of cells. We are developing materials and devices for the detection of biological species, including HBV surface antigen.
Fig. 2. (a) MWCNT sensor for kinase assay, (b) Micro ELISA for detecting HBV antigen using
anodic aluminum oxide, (3) Micro/nano composite particle for antigen-antibody detection
■ Mathematical modeling and numerical analysis
Our research in this area includes numerical analysis of protein folding phenomena, transport processes in a microfluidic systems and semiconductor processes. Example of mathematical modeling is shown for the sequence of protein folding.
Fig.3 Sequence of protein folding of a globular protein
■ Model validation and parameter estimation in biological pathways and pharmacokinetic model
We are developing procedures for the systematic validation of pathway model and parameter estimation to understand the pathways for the death and survival of the cancer cells.
Figure is shown for TNF (Tumor Necrosis Factor) pathway.
Do Hyun Kim (김도현)